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目的 了解河北省张家口地区精神分裂症患者弓形虫感染状况,探讨弓形虫感染与精神分裂症之间的关系。方法 采用酶联免疫吸附试验对222例住院精神分裂症患者及78例健康体检者进行弓形虫循环抗原(CAg)、抗弓形虫抗体IgM、IgG检测。结果 张家口地区精神分裂症患者弓形虫感染率(14.86％)、CAg或IgM阳性率(10.36％)均高于健康体检者(3.85％)、(1.28％),两者之间差异均有显著性(P<0.05);33例弓形虫检测阳性患者中,CAg或IgM阳性率(69.7％)大于IgG阳性率(30.3％)(P<0.01)。结论 张家口地区精神分裂症患者弓形虫感染率高于健康人群,且活动性感染较严重,应加强对弓形虫病的认识,重视精神病患者的弓形虫感染情况。
Objective To understand the status of Toxoplasma infection in schizophrenia patients in Zhangjiakou area of Hebei province and to explore the relationship between Toxoplasma gondii infection and schizophrenia. Methods Enzyme-linked immunosorbent assay was used to detect Toxoplasma gondii antigens (CAg) and anti-Toxoplasma gondii antibodies IgM and IgG in 222 inpatients with schizophrenia and 78 healthy controls. Results Toxoplasma infection rate (14.86%) and CAg or IgM positive rate (10.36%) in schizophrenia patients in Zhangjiakou were significantly higher than those in healthy subjects (3.85%, 1.28%), both of which were significantly different (P <0.05). The positive rate of CAg or IgM in 33 TAPO positive patients (69.7%) was higher than that of IgG (30.3%) (P <0.01). Conclusion The prevalence of Toxoplasma gondii in schizophrenia patients in Zhangjiakou area is higher than that of healthy people, and the active infection is more serious. The knowledge of toxoplasmosis should be strengthened and the toxoplasmosis of mental patients should be emphasized.