患者男,30岁。反复发热伴全身酸痛1月余,全身无症状结节、肿块1周。皮肤科情况:面部、躯干、四肢多发浸润性青色或灰色结节和肿块,最大者4.0cm×2.5cm,质韧,无压痛。结合血液学检查,皮肤组织病理及免疫组化检查,诊断为急性单核细胞白血病(M5型),皮肤白血病。本例患者提示,皮肤科医生对于无症状皮损,应考虑内脏肿瘤的可能。 Male patient, 30 years old. Repeated fever with body aches more than 1 month, the whole body asymptomatic nodules, lumps for 1 week. Dermatology: facial, trunk, multiple limbs infiltrating cyan or gray nodules and lumps, the largest of 4.0cm × 2.5cm, quality and tough, no tenderness. Combined with hematological examination, skin histopathology and immunohistochemistry, the diagnosis of acute monocytic leukemia (M5), skin leukemia. This patient prompts, dermatologists for asymptomatic lesions, should consider the possibility of visceral tumors.