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目的观察使用前列地尔脂微球载体靶向制剂(PGEI)对患者中心静脉压(CVP)监测的影响。方法采用自身对照的方法对30例脑梗死患者先后使用生理盐水和前列地尔用药前后分别进行中心静脉压的监测并观察其变化。结果 30例患者使用生理盐水后中心静脉压无明显变化,而使用前列地尔后出现中心静脉压下降。结论前列地尔能降低中心静脉压,监测CVP时需要避开此药药效高峰期。
Objective To investigate the effect of PGEI on the monitoring of patients’ central venous pressure (CVP). Methods 30 cases of patients with cerebral infarction were treated with saline and the alprostadil were monitored before and after treatment with central venous pressure monitoring and the changes were observed. Results There was no significant change of central venous pressure in 30 patients after using saline, but the decrease of central venous pressure after using alprostadil. Conclusion Alprostadil can reduce the central venous pressure, monitoring the CVP need to avoid the drug efficacy peak.