【摘 要】
：
血管平滑肌细胞是血管壁中的主要细胞类型,处于复杂的基质微环境中.微环境中的力学因素(包括基质刚度、基质微纳拓扑结构以及基质对细胞的几何约束等)可影响平滑肌细胞表型与
【机 构】
：
北京大学基础医学院生理学与病理生理学系;教育部分子心血管重点实验室;国家卫生健康委员会心血管分子生物学与调节肽重点实验室,北京100191
论文部分内容阅读
血管平滑肌细胞是血管壁中的主要细胞类型,处于复杂的基质微环境中.微环境中的力学因素(包括基质刚度、基质微纳拓扑结构以及基质对细胞的几何约束等)可影响平滑肌细胞表型与功能.平滑肌细胞通过特定的机械力感受器感知基质微环境中的机械力刺激,并将机械信号转化为生物化学信号,调控下游基因表达与活性,从而影响平滑肌细胞的各种行为.血管平滑肌细胞行为的异常可破坏血管稳态,导致血管重塑.阐明平滑肌细胞如何感知与传导机械力刺激以及细胞外力学微环境如何调控平滑肌细胞的表型与功能,可为血管疾病的预防与治疗提供新的策略.
其他文献
Steps are distinctive features for estimating the movement of the upper and lower block of faults.However,studies about the influence of steps as a special type of discontinuity on cracking behaviors and strength of rock masses are limited.In this researc
转录因子X盒结合蛋白1 (X-box binding protein-1,XBP1)在未折叠蛋白反应中起关键作用.本研究旨在分析XBP1在小鼠早期妊娠过程中的表达和调节,探讨其与胚胎着床的相关性.分别
针对含概率盒-证据混合认知不确定参数声场的响应预测问题,提出了一种概率盒框架下的改进区间蒙特卡洛方法.该方法首先将混合认知不确定参数转换为纯概率盒形式,然后结合有限
A view is often more than just a piece of landscape,framed by the gaze and evoking emotion.Without diminishing these obvious 'tourismimportant' advantages of a
Mountain area is an important geographical unit of land,and its ecology is sensitive and fragile.Over the past few decades,human activities have caused dramatic
The operation and power generation of utility-scale solar energy infrastructure in desert areas are affected by changes in surface erosion processes resulting from the construction of solar photovoltaic(PV)power stations.However,few studies have addressed
The landslide hazards occurring in the complex geological genesis accumulation body are usually controlled by the coupling action of many internal and external
Crop production vulnerability to climate change in Northwest China depends upon multiple socio-ecological factors.Knowledge regarding the specific indicators an
Variations in the plate convergence direction have generally reflected on the kinematics of the major fault zones developed in the intercontinental parts of the
In the Loess Plateau in Northern China,repeated freeze-thaw(FT)cycles deteriorate the strength and structure of loess as a foundation soil,resulting in the inst