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酪氨酸激酶受体Tie-2表达于血管内皮细胞(EC)和早期造血细胞,具有免疫球蛋白样环形结构和表皮生长因子同源结构域,曾经被认为是孤儿受体。Davis等1996年首次报道其配体血管形成素(angiopoietin,Ang)-1结合到Tie-2引起受
The tyrosine kinase receptor Tie-2 is expressed in vascular endothelial cells (ECs) and early hematopoietic cells and has an immunoglobulin-like loop and epidermal growth factor homology domain that was once considered an orphan receptor. Davis et al. First reported in 1996 that the binding of its ligand angiopoietin (Ang) -1 to Tie-2