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目的:用两种不同浓度脂肪乳剂灌胃法建立大鼠高脂血症模型,并对其血脂水平进行评价,为合理建立高脂血症动物模型提供依据。方法:将30只150～180g健康雄性SD大鼠随机分为正常对照组、低浓度脂肪乳剂组、高浓度脂肪乳剂组,每组10只。正常对照组大鼠每日给予基础饲料喂养,低浓度脂肪乳剂组和高浓度脂肪乳剂组大鼠于每天16∶00分别给予低浓度配方脂肪乳剂(20%猪油、6%胆固醇、0.2%丙基硫氧嘧啶、2%胆酸钠、10%吐温-80)和高浓度配方脂肪乳剂(30%猪油、10%胆固醇、1%丙基硫氧嘧啶、5%胆酸钠、20%吐温-80)灌胃1次,剂量为1ml/100g体重,其余时间给予基础饲料喂养,
OBJECTIVE: To establish hyperlipemia rat model with two different concentrations of fat emulsion gavage and to evaluate the level of blood lipid in order to provide a basis for the rational establishment of hyperlipemia animal model. Methods: Thirty healthy male SD rats (150-180 g) were randomly divided into normal control group, low fat emulsion group and high fat emulsion group, with 10 rats in each group. The rats in the normal control group were fed with basal diet daily. The rats in the low-fat emulsion group and the high-fat emulsion group were given the low-fat formulated fat emulsion (20% lard, 6% cholesterol, 0.2% (30% lard, 10% cholesterol, 1% propylthiouracil, 5% sodium cholate, 20% sodium cholate, 10% Tween- Tween -80) gavage 1, the dose of 1ml / 100g body weight, the rest of the time to give basic feed,