高危神经母细胞瘤是幼儿及青少年中高发型恶性疾病,为胚胎性肿瘤,其表面高度表达神经节苷脂GD2,故GD2成为此类恶疾的治疗靶标。在过去几十年中,抗GD2抗体疗法用于神经母细胞瘤的治疗研究取得了巨大进展,其安全性和有效性得到了充分验证。简介GD2的生物合成、结构与功能,综述用于神经母细胞瘤的抗GD2抗体疗法及其有效性的提高策略。 High-risk neuroblastoma is a high-risk malignant disease in young children and adolescents. It is an embryonal tumor with high expression of ganglioside GD2 on the surface. Therefore, GD2 has become the target of such ailments. Over the past few decades, anti-GD2 antibody therapies for the treatment of neuroblastoma made great progress, its safety and effectiveness have been fully validated. Introduction The biosynthesis, structure and function of GD2 are reviewed. The anti-GD2 antibody therapy for neuroblastoma and the strategy of improving its efficacy are reviewed.