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目的 :了解多环芳烃接触者遗传指标和血清癌基因蛋白P2 1表达水平及其在肺癌早期诊断中的意义 ,为多环芳烃作业者的劳动保护提供科学依据。方法 :对接触多环芳烃化合物的焦炉工 2 4名、沥青工 2 7名和健康对照组 31名的染色体畸变率和血清癌基因蛋白P2 1水平进行了检测。结果 :染色体异常检出率 ,焦炉工和沥青工均显著高于对照组 (P <0 .0 0 5 ) ;染色体裂隙次数 ,焦炉工和沥青工均显著高于对照组 (P <0 .0 1) ;染色体结构、数目畸变数 ,焦炉工显著高于对照组 (P <0 .0 1)。血清P2 1水平 ,焦炉工、沥青工均显著高于对照组 (P <0 .0 5 ) ,沥青工显著高于焦炉工 (P <0 .0 5 )。结论 :多环芳烃化合物具有遗传毒性 ,并可致血清P2 1蛋白水平升高。
OBJECTIVE: To understand the genetic parameters of PAHs contacts and the expression of serum oncogene protein P2 1 and its significance in the early diagnosis of lung cancer, and provide a scientific basis for the labor protection of PAHs workers. Methods: The chromosome aberration rate and serum oncogene protein P2 1 level of 24 coke oven workers, 27 asphaltene workers and 31 healthy controls were detected. Results: The detection rates of chromosomal abnormalities, coke oven workers and asphalt workers were significantly higher than those of the control group (P <0.05). The number of chromosome fissures, coke oven workers and asphalt workers were significantly higher than those of the control group (P0.01) .0 1). The chromosome structure, the number of distortion, coke oven workers were significantly higher than the control group (P <0.01). Serum P2 1 level, coke oven workers and asphalt workers were significantly higher than the control group (P <0.05), asphalt workers was significantly higher than coke oven workers (P <0.05). CONCLUSION: Polycyclic aromatic hydrocarbons are genotoxic and cause elevated levels of P2 1 protein.