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目的通过对不良孕产史夫妇进行外周血染色体核型分析,探讨异常及多态性核型与不良孕产史之间的关系。方法抽取585对不良孕产史夫妇的外周血进行体外培养,常规方法制片,G显带染色体核型分析。结果 1170受检者中检出异常核型28例,检出率2.39%多态性核型58例,占4.96%。结论染色体异常是导致不良孕产史的最主要原因,多态性核型也可导致不良孕产。
Objective To investigate the relationship between abnormal and polymorphic karyotypes and poor pregnancy history by analyzing the karyotypes of peripheral blood in couples with unhealthy pregnancy. Methods A total of 585 pairs of poor pregnancy and husband’s history of peripheral blood were cultured in vitro, G-banding karyotype analysis. Results Among the 1170 subjects, 28 cases were detected with abnormal karyotype, with a detection rate of 2.39%, 58 cases (4.96%). Conclusion Chromosomal abnormalities are the leading cause of adverse pregnancy history. Polymorphic karyotype may also lead to poor pregnancy.