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目的探讨孕妇血清IL6与胎膜早破及绒毛膜羊膜炎的关系。方法2004年1～10月中山大学附属第三医院对46例胎膜早破孕妇和50例正常孕妇,采用ELISA法测定血清IL6质量浓度,分娩时胎盘胎膜送病理检查。结果胎膜早破孕妇血清IL6质量浓度明显高于对照组,并随破膜时间的延长其含量升高(P<0.05),而且有绒毛膜羊膜炎者血清IL6高于无绒毛膜羊膜炎者及对照组(P<0.01);38例自然临产的胎膜早破孕妇中,血清IL6≥30ng/L者,其取样距临产时间短于血清<30ng/L者(P<0.05)。结论血清IL6含量升高对早期诊断胎膜早破合并绒毛膜羊膜炎及预测分娩具有重要意义。
Objective To explore the relationship between serum IL6 in pregnant women and premature rupture of membranes and chorioamnionitis. Methods From January to October 2004, 46 pregnant women with premature rupture of membrane and 50 normal pregnant women from the Third Affiliated Hospital of Sun Yat-sen University were enrolled. Serum IL6 concentration was measured by ELISA. The placenta fetal membranes were sent for pathological examination during delivery. Results The serum concentration of IL6 in pregnant women with premature rupture of membranes was significantly higher than that in the control group, and the content of IL6 was increased with the prolongation of rupture of membranes (P <0.05). The serum IL6 in chorioamnionitis was higher than those without chorioamnionitis (P <0.01). Among 38 pregnant women with spontaneous preterm premature rupture of membrane, the serum IL6≥30ng / L was shorter than that of serum <30ng / L (P <0.05). Conclusion The increase of serum IL6 level is of great significance for the early diagnosis of premature rupture of membranes combined with chorioamnionitis and prediction of childbirth.