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肾小管上皮细胞在发生发育过程中不断增殖、迁移,并通过会聚性延伸使肾小管得以延长。Wnt介导的信号转导从早期诱导阶段到晚期小管上皮成熟阶段均发挥着重要的调节作用。同时,分布在不同区域的肾小管上皮细胞通过其顶端、底部及侧面表达不同蛋白复合物而极化和节段化,并行使不同功能。Par家族、Crumbs、Scribbles等蛋白分子在小管上皮细胞极化形成中起重要调节作用。其中,具有高度特异性的细胞侧面如紧密连接的形成,成为肾小管屏障功能和栅栏功能的保证。Micro-RNA200基因能够以囊性肾病基因Pkd1为作用靶点来调节肾小管的成熟,从而保证其正常结构的形成和功能的发挥。
Tubular epithelial cells continue to proliferate and migrate during development and extend the renal tubules through convergent extension. Wnt-mediated signal transduction plays an important regulatory role from the early induction phase to the late tubular epithelial maturation phase. At the same time, tubular epithelial cells distributed in different regions are polarized and segmented by expressing different protein complexes at the apical, basal and lateral sides and exert different functions. Protein molecules such as the Par family, Crumbs and Scribbles play an important regulatory role in the tubular epithelial cell polarization. Among them, the highly specific formation of the cell side, such as tight junctions, serves as a guarantee of renal tubular barrier function and barrier function. Micro-RNA200 gene to cystic nephropathy gene Pkd1 as a target to regulate tubular maturation, so as to ensure the formation of its normal structure and function.