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目的研究尿毒症患者血浆总同型半胱氨酸(tHcy)浓度及叶酸联合甲钴胺对其干预治疗的效果。方法采用荧光偏振免疫法检测60例尿毒症患者(治疗组)和40名健康人(正常对照组)血浆tHcy浓度,并对尿毒症伴高Hcy血症患者用叶酸联合甲钴胺进行干预治疗,治疗8wk后再次测定其血浆tHcy浓度。结果治疗前治疗组血浆tHcy浓度显著高于正常对照组(P<0.01);治疗后治疗组血浆tHcy浓度较治疗前明显下降(P<0.01)。结论尿毒症患者普遍存在高Hcy血症,叶酸联合甲钴胺可显著降低尿毒症患者血浆tHcy浓度。
Objective To study the plasma total homocysteine (tHcy) concentration in patients with uremia and the effect of folic acid combined with mecobalamin on it. Methods Plasma tHcy concentrations were measured in 60 patients with uremia (treatment group) and 40 healthy persons (normal control group) by fluorescence polarization immunoassay. The patients were treated with folic acid and mecobalamin for uremic patients with hyperactivity of Hcy. Plasma tHcy concentrations were measured again after 8 weeks of treatment. Results The plasma tHcy concentration in the treatment group before treatment was significantly higher than that in the normal control group (P <0.01). The plasma tHcy concentration in the treatment group was significantly lower than that before treatment (P <0.01). Conclusions Hyperhomocysteinemia is common in patients with uremia. Folic acid combined with mecobalamin significantly reduces the plasma tHcy concentration in uremic patients.