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目的 加深对粘膜相关淋巴组织 (MALT)型淋巴瘤的认识。方法 复阅胃肠道MALT型淋巴瘤 30例 ,在HE诊断基础上做HP染色和免疫组化LCA、CD2 0、κ、λ、CK标记。结果 胃 16例 ,肠 14例。临床主要表现为腹胀腹痛 ,黑便或血便 ,腹部包块。病理改变以边缘区B细胞 (中心细胞样细胞 )为主 ,13例出现变异大细胞 ,3例以变异大细胞为主。 2 5例有淋巴上皮 (LEL)病变 ,18例有淋巴滤泡结构 ,2 1例见浆细胞浸润。17例HP阳性 ,30例CD2 0阳性。结论 胃肠道MALT型淋巴瘤与HP感染关系密切。低度恶性的MALT型淋巴瘤可向中度恶性或高度恶性淋巴瘤转化
Objective To deepen the understanding of mucosa-associated lymphoid tissue (MALT) lymphoma. Methods Thirty patients with gastrointestinal MALT lymphoma were retrospectively reviewed. HP staining and immunohistochemical staining of LCA, CD20, κ, λ and CK were performed on the basis of HE diagnosis. Results stomach in 16 cases, 14 cases of intestinal. The main clinical manifestations of abdominal pain abdominal pain, melena or bloody stool, abdominal mass. Pathological changes in the marginal zone B cells (centrocyte-like cells), 13 cases of large cell variant, 3 cases of large variant cells. Twenty-five had lymphatic epithelial (LEL) lesions, 18 had lymphoid follicular structures and 21 had plasma cell infiltration. 17 cases of HP positive, 30 cases of CD20 positive. Conclusion Gastrointestinal MALT lymphoma is closely related to HP infection. Low grade MALT lymphoma can be transformed into moderately malignant or highly malignant lymphoma