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目的对缬沙坦联合苯磺酸氨氯地平治疗社区高血压病伴随糖尿病患者的临床疗效进行分析研究。方法将120例患者根据随机数字法分为两组,观察组60例服用氨氯地平(5mg/d)基础上加服用缬沙坦(80mg/d);对照组60例仅服用缬沙坦(80mg/d),比较两组患者治疗4个月后的血压水平、血糖水平,并观察患者的相关不良症状。结果观察组患者血压控制总有效率为91.7%,对照组患者的总有效率68.3%,观察组疗效明显优于对照组患者(P<0.05)。两组患者收缩压与舒张压治疗后比治疗前均有显著降低(P<0.05),并且观察组患者治疗后收缩压与舒张压明显低于对照组(P<0.05)。两组患者治疗后空腹血糖、血肌酐水平均有所改善,但与治疗前比较差异无统计学意义(P>0.05),治疗后两组的血糖与血肌酐差异无统计学意义(P>0.05)。并且两组患者在服用前期均有少量的不良反应,患者未予以特殊处理,随着服用时间延长症状逐渐缓解,两组患者的不良反应发生情况比较差异无统计学意义(P>0.05)。结论缬沙坦联合氨氯地平治疗社区高血压合并糖尿病患者可以有效控制患者血压临床疗效确切,不良反应小,安全性高,值得临床推广使用。
Objective To investigate the clinical efficacy of valsartan and amlodipine besylate in the treatment of community-based hypertensive patients with diabetes mellitus. Methods One hundred and twenty patients were divided into two groups according to the random number method: 60 patients in the observation group received valsartan (80mg / d) on the basis of amlodipine (5mg / d); 60 patients in the control group received only valsartan 80mg / d). The blood pressure and blood glucose level were compared between the two groups after 4 months of treatment, and the adverse symptoms of the patients were observed. Results The total effective rate of blood pressure control in observation group was 91.7%, while the total effective rate in control group was 68.3%. The observation group had better curative effect than the control group (P <0.05). The systolic blood pressure and diastolic blood pressure in both groups were significantly lower than those before treatment (P <0.05), and the systolic and diastolic blood pressures in the observation group were significantly lower than those in the control group after treatment (P <0.05). Fasting blood glucose and serum creatinine were improved in both groups after treatment, but there was no significant difference between before and after treatment (P> 0.05). There was no significant difference between the two groups in blood glucose and serum creatinine (P> 0.05 ). There was a small amount of adverse reactions in both groups before treatment. The patients were not treated specially. With the gradual remission of symptoms, the two groups experienced no significant difference in adverse reactions (P> 0.05). Conclusions Valsartan combined with amlodipine can effectively control the blood pressure of patients with hypertension in community. The clinical curative effect of the combination of valsartan and amlodipine is small, the adverse reactions are small and the safety is high. It is worth to be used clinically.