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目的 检测一种植物相关人肿瘤抗原在乳腺癌、乳腺良性病变和正常乳腺组织中的表达 ,并探讨其临床意义。方法 采用S P免疫组织化学方法 ,检测该抗原在 5例正常乳腺组织、2 0例乳腺纤维腺瘤和 136例原发性乳腺癌中的表达。结果 植物相关人肿瘤抗原在乳腺正常组织中无表达 ;在乳腺纤维腺瘤中 ,表达阳性率为 2 0 .0 % ,且表达强度较低 ;在乳腺癌组织中 ,该抗原阳性表达率为 85 .3% ,与前两者相比 ,差异有极显著性 (P <0 .0 1) ,其表达水平与乳腺癌的组织学分级 (P <0 .0 5 )、浸润 (P <0 .0 1)和复发 (P <0 .0 5 )密切相关。结论 植物相关人肿瘤抗原在乳腺癌的发生发展过程中可能起重要作用 ,是一种具有潜在乳腺癌诊断价值的肿瘤标志物。
Objective To detect the expression of a plant-associated human tumor antigen in breast cancer, benign breast lesions and normal breast tissues and to explore its clinical significance. Methods SP immunohistochemistry was used to detect the expression of this antigen in 5 cases of normal breast tissue, 20 cases of breast fibroadenoma and 136 cases of primary breast cancer. Results The tumor-associated antigen in plant was not expressed in normal breast tissue. In breast fibroadenoma, the positive rate was 20.0% and the expression intensity was low. In breast cancer tissues, the positive rate of this antigen was 85 .3%, respectively. There was a significant difference between the two groups (P <0.01). The expression level was significantly correlated with histological grade (P <0.05) and infiltration (P < 0 1) and relapse (P <0.05). Conclusion Plant-associated tumor antigens may play an important role in the development of breast cancer, which is a tumor marker with diagnostic potential for breast cancer.