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目的研究游离前列腺特异性抗原(fPSA)及总前列腺特异性抗原(tPSA)的比值(f/tPSA)对前列腺癌(PCa)鉴别诊断的价值。方法检测fPSA与tPSA并算出比值f/tPSA;同时算出不同f/tPSA所对应的特异性和敏感性。结果在4-10ng/ml的诊断灰区,PCa组与前列腺增生(BPH)组间血清中fPSA和tPSA的水平均无显著差异,而f/tPSA比值,PCa组(0.12±0.05)和BPH组(0.28±0.09)间差异显著(P<0.001)。结论在诊断灰区对前列腺癌的鉴别诊断,用f/tPSA比值比单独用tPSA及fPSA更有价值,诊断鉴别点以f/tPSA<0.19较为合适。
Objective To investigate the value of f / tPSA (free prostate specific antigen (fPSA) and total prostate specific antigen (tPSA)) in the differential diagnosis of prostate cancer (PCa). Methods The fPSA and tPSA were tested and the ratio f / tPSA was calculated. The specificity and sensitivity of different f / tPSA were also calculated. Results There was no significant difference in serum fPSA and tPSA levels between the 4-10 ng / ml diagnostic gray zone, PCa group and benign prostatic hyperplasia (BPH) group, while the f / tPSA ratio in PCa group (0.12 ± 0.05) and BPH group (0.28 ± 0.09) significant difference (P <0.001). Conclusions In the diagnosis of gray zone for the differential diagnosis of prostate cancer, f / tPSA ratio than tPSA alone and fPSA more valuable, differential diagnosis point f / tPSA <0.19 more appropriate.