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This study was aimed to investigate the level of sEGF in CAG with different therapies of either Chinese traditional medicine or western medicine. Patients were divided into spleen-reinforcingⅠ, spleen-reinforcing Ⅱ,dampness-resolving and western medicine group by Differentiation Syndrome. Healthy volunteers acted as controls. The sEGF was investigated before and after treatment. The level of sEGF in CAG was higher than that in control group(P