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目的检测发育性髋关节脱位(DDH)髋关节囊中雌激素受体(ER)的表达,探讨ER与DDH病因的关系。方法收集新鲜DDH髋关节囊标本25例(DDH组),标本来源于DDH患儿术中紧缩缝合后切除的多余关节囊,按年龄和性别分组:2～5岁组18例,6～14岁组7例;男性组4例,女性组21例。健康对照组16例,标本来源于小儿髋部毁损伤、尸体及尸检,按年龄和性别分组:2～5岁11例,6～14岁5例;男性组3例,女性组13例。采用免疫组织化学法行ER检测。结果 DDH组ER阳性率为80.0%,其中2～5岁组为83.3%,6～14岁组为71.4%;女性组为90.5%,男性组为25.0%。健康对照组ER阳性率为31.3%。DDH组ER阳性率高于健康对照组(P<0.05),女性组高于男性组(P<0.05),2～5岁组与6～14岁组间比较,差异无统计学意义(P>0.05)。结论 ER在DDH髋关节囊中的表达较高,且女性高于男性,与年龄无明显关系,可能是导致髋关节囊松弛和DDH发病的原因之一。
Objective To detect the expression of estrogen receptor (ER) in the hip joint capsule of patients with developmental hip dislocation (DDH) and to explore the relationship between ER and DDH. Methods Totally 25 cases of fresh DDH hip capsule (DDH group) were collected. The specimens were obtained from the patients with DDH who underwent resection of the redundant joint capsule after surgery. According to the age and sex, 18 cases were aged from 2 to 5 years and 6 to 14 years old Group 7 cases; 4 males and 21 females. The healthy control group consisted of 16 cases. The specimens were from pediatric injury, corpse and autopsy. The patients were divided into two groups according to their age and gender: 11 cases of 2 to 5 years old and 5 cases of 6 to 14 years old; 3 cases of male and 13 cases of female. Using immunohistochemical method of ER detection. Results The positive rate of ER in DDH group was 80.0%, of which 83.3% in 2 ~ 5 years old group, 71.4% in 6-14 years old group, 90.5% in female group and 25.0% in male group. The positive rate of ER in healthy control group was 31.3%. The positive rate of ER in DDH group was significantly higher than that in healthy control group (P <0.05), but higher in female group than in male group (P <0.05). There was no significant difference between 2 ~ 5 years old group and 6 ~ 14 years old group (P> 0.05). Conclusions The expression of ER is higher in DDH capsulorum, and the female is higher than male, and has no obvious relationship with age, which may be one of the reasons leading to the relaxation of hip joint capsule and DDH.