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肺小细胞癌是一种恶性程度极高、早期出现全身转移的肿瘤,约占肺癌的20～30％,对化疗、放疗较为敏感,治疗后多可获暂时缓解、改善预后。但近年来肺小细胞癌的治疗未出现新的进展,一般认为其中最有效的治疗是自身骨髓移植合并大剂量抗癌药物的根治疗法。骨髓移植作为白血病或恶性淋巴瘤的根治疗法已获认可,并试用于肺小细胞癌。由于肺小细胞癌极易发生骨髓转移,因此采用单克隆抗体去除患者骨髓已浸润的肿瘤细胞极为便利。目前,已有几种单克隆抗体可用于去除骨
Pulmonary small cell carcinoma is a type of tumor with a very high degree of malignancy and early systemic metastasis, accounting for about 20 to 30% of lung cancer. It is sensitive to chemotherapy and radiotherapy. After treatment, it can be temporarily relieved and the prognosis improved. However, no new progress has been made in the treatment of small cell lung cancer in recent years, and the most effective treatment is generally considered to be the root therapy of autologous bone marrow transplantation combined with large-dose anticancer drugs. Bone marrow transplantation has been approved as a root therapy for leukemia or malignant lymphoma and has been tested for small cell lung cancer. Because small cell lung cancer is prone to bone marrow metastases, it is extremely convenient to use monoclonal antibodies to remove infiltrating tumor cells in the patient’s bone marrow. At present, several monoclonal antibodies have been used to remove bone