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本文作者在1980年初至1983年底的4年期间对丹麦7238例中期妊娠作羊膜腔穿刺染色体检查的妇女随访其自然流产发生率(只有9例失访占0.1%)。自然流产的标准是胎儿于孕28周前娩出或胎死宫内。所有羊膜腔穿刺皆在超声波下进行,因此贯穿胎盘在超声波屏幕上显示出来。在7181例单胎中139例(1.9%)发生流产,48例双胎中6例(12.5%)发生流产。羊膜腔穿刺贯穿胎盘有1098例(15.1%),血液污染羊水有1019例(14%),前者流产的发生率增加一倍,而后者流产的发生率增加一倍多。作者认为穿刺羊膜腔时贯穿胎盘可能在胎盘后形成血肿并逐渐增大而引起流产。作者又分析了如果妊娠早期曾有出血及穿刺的胎龄≤14周或≥20周,穿刺易贯穿胎盘及血液污染羊水。羊膜腔穿刺超过1次
The authors examined the spontaneous abortion rate (only 9 out of 10% missed) of women who underwent amniocentesis during the four-year period from early 1980 to the end of 1983 in Denmark. The standard of natural abortion is the fetus delivered 28 weeks before pregnancy or fetal death. All amniocentesis is performed under ultrasound and therefore appears across the placenta on the ultrasound screen. Abortion occurred in 139 (1.9%) of 7181 singletons and abortion in 6 of 48 (12.5%) twins. Amniocentesis 1098 cases (15.1%) through the placenta, 1019 cases of blood contamination of amniotic fluid (14%), the former double the incidence of miscarriage, while the latter the incidence of miscarriage more than doubled. The authors believe that when the amniotic puncture through the placenta may be formed after the placenta and gradually increase the hematoma caused by miscarriage. The authors also analyzed if early gestational age had bleeding and punctate gestational age ≤ 14 weeks or ≥ 20 weeks, puncture easily run through the placenta and blood amniotic fluid. Amniocentesis more than 1 time