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目的探讨单树脂肝素抗凝法在血液灌流中的应用效果。方法将需要进行血液灌流治疗的35例患者共计106次按治疗的先后顺序分为对照组17例(52次)和观察组18例(54次),对照组采用常规的全程肝素法进行抗凝,观察组采用改进后的单树脂肝素法进行抗凝,统计两组血液灌流达到肝素化的平均时间、两组凝血(APTT)时间延长次数、管路凝血次数、发生血栓次数。结果观察组完成抗凝肝素化所需时间短于对照组、凝血时间(APTT)延长次数少于对照组,差异有统计学意义(P<0.01);两组发生管路内凝血及血栓的次数差异无统计学意义(P>0.05)。结论通过改进血液灌流抗凝方法,减少了肝素的用量及肝素化的时间,降低患者出血危险性,保障了患者抢救的黄金时间,值得临床推广。
Objective To investigate the effect of single resin heparin anticoagulation in hemoperfusion. Methods Thirty-five patients in need of hemoperfusion were divided into control group (n = 17) (52 times) and observation group (n = 106) according to the order of treatment. The control group received conventional heparin . The observation group was treated with improved single resin heparin method for anticoagulation. The average time for hemoperfusion to achieve heparinization was calculated in both groups. The time of APTT prolongation, the number of coagulation of blood vessels and the number of thrombosis were also observed. Results The duration of anticoagulant heparinization in observation group was shorter than that in control group, and the number of APTT prolongation was less than that in control group (P <0.01). The number of coagulation and thrombosis The difference was not statistically significant (P> 0.05). Conclusion By improving hemoperfusion anticoagulant method, the dosage of heparin and heparinized time are reduced, the risk of bleeding in patients is reduced, and the prime time of patients’ rescue is guaranteed, which is worthy of clinical promotion.