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目的:探讨2型糖尿病患者伴非酒精性脂肪性肝病(NAFLD)与颈动脉粥样硬化的关系。方法:对入选168例2型糖尿病住院患者,根据超声检查结果分为两组,其中合并NAFLD组104例,无NAFLD64例为对照组。采用颈部血管彩色多普勒超声检查,测定颈动脉内膜中层厚度(IMT),有无斑块形成及管腔狭窄。同时分析各入选者的各项临床生化指标。结果:两组间糖尿病病程、体质指数、血压、甘油三酯、空腹血糖、糖化血红蛋白及颈动脉内膜中层厚度各项临床指标差别均有统计学意义(P<0.05);2型糖尿病患者伴NAFLD组中颈动脉硬化、斑块形成及管腔狭窄发生率分别为78.85%、40.38%和25.00%,均高于对照组(P<0.05);颈动脉粥样硬化与2型糖尿病是否合并NAFLD有正相关关系(r=0.238,P<0.01)。结论:2型糖尿病患者颈动脉粥样硬化与合并NAFLD密切相关,对2型糖尿病并NAFLD应尽早行血管超声检查具有重要的临床意义。
Objective: To investigate the relationship between type 2 diabetes with non-alcoholic fatty liver disease (NAFLD) and carotid atherosclerosis. Methods: A total of 168 patients with type 2 diabetes admitted to hospital were divided into two groups according to the results of ultrasonography. There were 104 NAFLD patients and 64 non-NAFLD patients as control group. Cervical artery color Doppler echocardiography was used to measure carotid intima-media thickness (IMT), plaque formation and stenosis. At the same time analysis of the various candidates for the clinical and biochemical indicators. Results: There were significant differences in the clinical parameters of diabetes course, body mass index, blood pressure, triglyceride, fasting blood glucose, glycosylated hemoglobin and carotid artery intima-media thickness between the two groups (P <0.05). Patients with type 2 diabetes mellitus The incidence of carotid atherosclerosis, plaque formation and stenosis in NAFLD group were 78.85%, 40.38% and 25.00%, respectively, which were higher than those in control group (P <0.05). Whether NAFLD was associated with carotid atherosclerosis and type 2 diabetes mellitus There was a positive correlation (r = 0.238, P <0.01). Conclusion: Carotid atherosclerosis is closely related to NAFLD in patients with type 2 diabetes mellitus, which has important clinical significance for type 2 diabetes and NAFLD as soon as possible.