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本文采用随机、双盲、安慰剂对照的交叉试验比较地尔硫(艹卓)和硝苯啶对冠状动脉痉挛所致心绞痛的疗效和安全性。对单用一药无效者,在非盲条件下观察两药合用的效果。方法:平均年龄58(35～74)岁的15(男12、女3)例患者,在静息和日常活动中均有缺血性胸痛,舌下含服硝酸甘油则缓解。造影资料表明,在自发或麦角新碱诱发心绞痛时均有冠脉痉挛。试验分5期:1.首次单盲安慰剂期(2周):各例静息时心绞痛发
This randomized, double-blind, placebo-controlled crossover trial compared the efficacy and safety of diltiazem and nifedipine against angina pectoris caused by coronary artery spasms. For those who are ineffective with single drug, observe the combined effect of the two drugs under the condition of non-blindness. METHODS: Fifteen (12 males, 3 females) with a mean age of 58 (35-74 years) had ischemic chest pain at rest and daily activity and sublingual nitroglycerin was relieved. Angiography data show that spontaneous or ergometrine induced angina pectoris when both have coronary spasm. Test points 5: 1. The first single-blind placebo (2 weeks): the case of resting angina pectoris