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目的探讨卵巢颗粒细胞瘤(Granulosa Cell Tumor,GCT)中血管内皮生长因子(vascular endothelial growth factor,VEGF)和环氧合酶-2(cyclooxygenase-2,COX-2)的表达及意义。方法用免疫组织化学S-P法检测47例GCT中VEGF和COX-2的表达。结果GCT中VEGF和COX-2阳性表达率分别为63.8%和55.3%;其中,VEGF在肿瘤大小和临床分期组间差异有统计学意义(P<0.05),而在病理组织分型和5年内复发组间差异无统计学意义(P>0.05);COX-2在肿瘤大小和病理组织分型组间差异均有统计学意义(P<0.05),而在临床分期和5年内复发组间差异无统计学意义(P>0.05)。GCT中VEGF和COX-2的阳性表达率均高于卵巢正常组织。结论VEGF和COX-2可能参与了卵巢颗粒细胞瘤的发生发展过程,其表达提示GCT预后不良。
Objective To investigate the expression and significance of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in granulosa cell tumor (GCT). Methods The expressions of VEGF and COX-2 in 47 cases of GCT were detected by immunohistochemical S-P method. Results The positive rates of VEGF and COX-2 in GCT were 63.8% and 55.3%, respectively. There was significant difference between the tumor size and the clinical stage (P <0.05) There was no significant difference between the two groups (P> 0.05). The difference of COX-2 between tumor size and pathological type was statistically significant (P <0.05), while between the clinical stage and 5-year recurrence group No statistical significance (P> 0.05). The positive rates of VEGF and COX-2 in GCT were higher than those in normal ovarian tissue. Conclusion VEGF and COX-2 may be involved in the development of ovarian granulosa cell tumor. The expression of VEGF and COX-2 may indicate the poor prognosis of GCT.