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A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method.The results showed that compound 15,5-[3-methoxy-4-(pyridine-3-yl)benzyl]-2,4-diamino pyrimidine,had an IC_(50) of 1.45μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice (NFS-60),which was similar with GW2580,a selective inhibitor of c-Fms kinase.
A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method. The results showed that compound 15,5- [3-methoxy-4- (pyridine-3-yl) benzyl] -2,4-diamino pyrimidine, had an IC 50 of 1.45 μmol / L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice was similar with GW2580, a selective inhibitor of c-Fms kinase.