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目的比较不同年龄消化性溃疡患者的临床特点。方法共263例消化性溃疡患者,对不同年龄组的主要症状、溃疡发生的部位、与NSAIDs相关性、伴随的慢性疾病以及治疗和转归等进行比较。结果老年组有典型症状者显著少于中青年组;老年组和中青年组胃溃疡分别占47.6%和26.9%(P=0.001);两组胃多发溃疡分别占13.1%和5.1%(P=0.022);溃疡直径≥2cm者分别占17.8%和9.0%(P=0.012);恶性胃溃疡分别占22.4%和1.9%(P<0.001);伴存病分别占75.7%和18.6%(P<0.001),与NSAIDs相关的溃疡老年组与中青年组分别为35.5%和10.3%(P<0.001)。结论老年人消化性溃疡患者症状不典型,胃溃疡、胃多发溃疡、巨大溃疡和恶性胃溃疡构成比高,老年人伴存疾病多。
Objective To compare the clinical features of peptic ulcer patients of different ages. METHODS: A total of 263 patients with peptic ulcer were enrolled in this study. The main symptoms of different age groups, the location of the ulcer, the association with NSAIDs, the associated chronic diseases, and the treatment and outcome were compared. Results The incidence of gastric ulcer in the elderly group was significantly lower than that in the middle-aged group (47.6%, 26.9%, respectively) (P = 0.001). Gastric ulcers in both groups accounted for 13.1% and 5.1%, respectively (P = 0.022). The ulcer diameter≥2cm accounted for 17.8% and 9.0%, respectively (P = 0.012). Malignant gastric ulcer accounted for 22.4% and 1.9% respectively (P <0.001), and concomitant disease accounted for 75.7% and 18.6% 0.001), 35.5% and 10.3% (P <0.001) for NSAIDs-related ulcers in older and younger adults, respectively. Conclusions The symptoms of peptic ulcer in the elderly are not typical. Gastric ulcer, multiple gastric ulcer, huge ulcer and malignant gastric ulcer constitute a high proportion, and the elderly often have associated diseases.