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目的 确定细胞间隙增大是否是人食管酸返流损伤的一种早期表现 .方法 用透射电镜检查 10例正常对照组、12例胃食管返流病 (GERD)患者、10例食管癌患者和 10例食管癌行“隧道式”食管胃吻合术后患者的内镜活检标本 ,用图像分析仪测量每例标本透射电镜照片的细胞间隙 .结果 胃食管返流病患者组 (1.2 7± 0 .77)μm和食管癌患者组的细胞间隙 (1.2 2± 0 .5 5 ) μm均大于正常对照组 (0 .49± 0 .0 8) μm,“隧道式”食管胃吻合术后患者组 (0 .5 5± 0 .11μm)与正常对照组细胞间隙无明显差异 .前两组分别有 9例和 7例细胞间隙≥ 2 .5 μm,而后两组无 1例细胞间隙≥ 2 .5 μm.结论 细胞间隙增大是人食管酸返流损伤的一种早期表现 ;食管癌患者同时存在 GERD;“隧道式”食管胃吻合术具有良好的抗返流效果
Objective To determine whether intercellular space enlargement is an early manifestation of human esophageal acid reflux injury. METHODS Transmission electron microscopy was used to examine 10 normal controls, 12 patients with gastroesophageal reflux disease (GERD), 10 patients with esophageal cancer, and 10 Endoscopic biopsy specimens of patients with esophageal cancer who underwent “tunnel” esophagogastric anastomosis were treated with an image analyzer to measure the cell gap of the TEM photographs of each specimen. Results Gastroesophageal reflux disease group (1.2 7 ± 0 .77) The gap between the μm and esophageal cancer patients was (1.2 2 ± 0.55) μm greater than that of the normal control group (0.49 ± 0.88 μm). The patients in the “tunnel” esophagogastric anastomosis group (0 There was no significant difference in the cell gap between .5 5 ± 0 .11μm) and the normal control group. In the first two groups, there were 9 and 7 cases with a cell gap ≥ 2. 5 μm, and in the latter two groups, none of the cases had a cell gap ≥ 2. 5 μm. Conclusion Increased cell gap is an early manifestation of human esophageal acid reflux injury; GERD exists in patients with esophageal cancer; “tunnel” esophagogastric anastomosis has good anti-reflux effect