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目的本文旨在探讨左旋咪唑预防食管癌的作用及与免疫的关系。方法Ｗｉｓｔａｒ大鼠９０只，随机分为三组，分别给左旋咪唑、太洛龙（阳性对照）、生理盐水（阴性对照），用甲基戊基亚硝胺ＭＡＮＡ诱发食管癌前病变，经１０５天实验后，检测食管癌前病变发生率，并测定免疫器官指数，外周血Ｔ淋巴细胞和自然杀伤细胞（ＮＫ细胞）。结果显示左旋咪唑降低食管癌前病变发生率的作用和太洛龙（Ｔｉｌ）相似，并使外周血Ｔ淋巴细胞和ＮＫ细胞明显增加。Ｔｉｌ组ＮＫ细胞无增加。结论左旋咪唑和太洛龙具有相似地预防亚硝胺诱发食管癌作用，并与增强机体免疫功能相关。
Purpose This article aims to investigate the role of levamisole in the prevention of esophageal cancer and its relationship with immunity. Methods Ninety Wistar rats were randomly divided into three groups: levamisole, tylosin (positive control) and normal saline (negative control) respectively. The premalignant esophageal lesions were induced by methylpentyl nitrosamine (MANA) After the experiment, the incidence of esophageal precancerous lesions was detected, and the index of immune organs, peripheral blood T lymphocytes and natural killer cells (NK cells) were measured. The results showed that levamisole reduce the incidence of esophageal precancerous lesions and the role of tollone (Til) similar, and the peripheral blood T lymphocytes and NK cells increased significantly. Til group no increase in NK cells. Conclusions Levamisole and tiaololong can prevent nitrosamine-induced esophageal cancer in a similar way and are related to the enhancement of immune function.