细胞自噬(Autophagy)的功能异常可引起许多疾病,恶性肿瘤是最早被发现与自噬有关的疾病之一。自噬在乳腺癌形成早期起到抑制作用,延迟细胞凋亡,而自噬缺陷会激活乳腺肿瘤中的DNA损伤反应,促进基因扩增,并协同凋亡缺陷加速乳腺肿瘤生长。本文将从自噬与乳腺癌的关系、在乳腺癌中beclin1基因的缺失或下调机制、利用自噬治疗不同病理分型乳腺癌的策略等方面进行综述。 The abnormal function of autophagy can cause many diseases, and malignancy is one of the earliest diseases associated with autophagy. Autophagy plays an inhibitory role in the early stage of breast cancer formation and delays apoptosis. Autophagy defect activates DNA damage response in breast tumors, promotes gene amplification, and cooperates with apoptosis defects to accelerate the growth of breast tumors. This article reviews the relationship between autophagy and breast cancer, the absence or downregulation of the beclin1 gene in breast cancer, and the strategy of using autophagy to treat different pathological types of breast cancer.