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【目的】探讨不同蓝光治疗方式对新生儿高胆红素血症的疗效及其对降钙素原(PCT)、胱抑素 C (Cys C)和炎性因子的影响。【方法】选择2008年1月至2013年8本院收治的212例新生儿高胆红素血症患儿为研究对象,采用随机数字表法分为对照组和观察组,每组各106例,其中对照组患儿给予持续蓝光照射治疗,而观察组则采用间断性蓝光照射治疗,对比两组患儿临床疗效、血液生化指标、PCT、Cys C 和炎性因子的变化水平。【结果】观察组患儿总体有效率为95.28%,略高于对照组的91.51%,但两组间比较差异并无统计学意义(P >0.05);对照组患儿的不良反应发生率为23.58%;显著高于观察组的6.60%(P 0.05);the incidence rate of the ad-verse reaction of patients in the control group was 23.58%,showing significantly higher than the 6.60% of the observation group (P <0.05).After treatment,serum bilirubin,albumin,bilirubin/albumin ratio,Cys C and IL-6 contents were significantly reduced in both two groups,and the efficacy of the observation group was sig-nificantly less than that in the control group (P 0.05).[Conclusion]Intermittent blue light therapy can signif-icantly reduce the adverse reaction of neonatal hyperbilirubinemia,and improve the level of IL-6 and Cys C.