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干扰素-γ(interferon-γ,IFN-γ)是重要的辅助型T细胞-1型(type-1 helper T-cell,Th1)细胞因子,它作为抗原提呈细胞和淋巴细胞增殖、分化的调节剂,参与机体的炎症反应和抗病毒免疫。细胞因子的基因多态性影响细胞因子的表达水平,导致个体间免疫反应的差异,最终影响感染后的发展趋势和临床转归。本文主要就IFN-γ基因多态性与乙型肝炎病毒(hepatitis B virus,HBV)自发清除、感染慢性化、肝硬化、肝癌及抗病毒治疗的相关研究进行评述。
Interferon-γ (IFN-γ) is an important type-1 helper T-cell (Th1) cytokine which acts as a proliferation and differentiation antigen-presenting cell and lymphocyte Regulators, involved in the body’s inflammatory response and anti-viral immunity. Cytokine gene polymorphisms affect the expression of cytokines, leading to differences in immune responses among individuals, eventually affecting the post-infection trends and clinical outcomes. This article mainly reviews the related studies on IFN-γ gene polymorphism and spontaneous clearance of hepatitis B virus (HBV), chronic infection, liver cirrhosis, liver cancer and antiviral therapy.