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目的检测乳腺癌患者术前及术后血清胰岛素样生长因子-1的水平。方法应用双位点免疫放射测定法(IRMA)对不同TNM分期的49例乳腺癌患者术前、术后外周血中IGF-1水平进行检测,20例健康志愿者设为正常对照。结果乳腺癌患者手术前后血清IGF-1水平均高于正常对照(P<0.05),手术前后乳腺癌患者血清IGF-1水平差异无统计学意义(P>0.05)。结论乳腺癌患者血清IGF-1参与乳腺癌的发病过程,是乳腺癌发生、发展过程中的重要因子。
Objective To detect the serum level of insulin-like growth factor-1 before and after breast cancer patients. Methods The levels of IGF-1 in preoperative and postoperative peripheral blood of 49 cases of breast cancer patients with different TNM stages were detected by dual-site immunoradiometric assay (IRMA). Twenty healthy volunteers were enrolled as normal controls. Results The serum levels of IGF-1 in patients with breast cancer before and after operation were significantly higher than those in controls (P <0.05). There was no significant difference in serum IGF-1 level between patients with breast cancer before and after operation (P> 0.05). Conclusion Serum IGF-1 in breast cancer patients is involved in the pathogenesis of breast cancer and is an important factor in the development and progression of breast cancer.