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盐酸氟苯桂嗪(flunarizine hydrochloride)是一种具有脑动脉扩张作用的钙拮抗剂。广泛用于治疗脑梗塞后遗症、脑出血后遗症、脑动脉硬化等。对偏头痛和各种原因所致的眩晕也有效。但该药对中枢神经系统有严重的毒性,常可引起震颤麻痹综合征、抑郁症、不自主运动等。以往有作者认为该药副作用少,主要是胃肠症状,偶见 GOT 和 GPT 呈一过性增高。但自今春以来作者即发现4例由该药诱发的震颤麻痹综合征。4例均为女性,年龄64～89岁,每日服用氟苯桂嗪10mg,服后2周～6个月出现步态障
Flunarizine hydrochloride is a calcium antagonist with cerebral artery dilatation. Widely used in the treatment of cerebral infarction sequelae, sequelae of cerebral hemorrhage, cerebral arteriosclerosis and so on. It is also effective for migraines and dizziness caused by various causes. However, the drug has serious toxicity to the central nervous system, often causing paralysis syndrome, depression, involuntary movements. In the past, some authors believe that the side effects of the drug is less, mainly gastrointestinal symptoms, occasionally GOT and GPT showed a transient increase. But since the beginning of spring, the authors found four convulsive paralysis syndromes induced by the drug. 4 cases were female, aged 64 to 89 years, daily use of flubenzuron 10mg, after 2 weeks to 6 months after the occurrence of gait disorder