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白细胞介素11(IL-11)是一种对免疫应答、造血、急性炎症反应、以及脂肪细胞、神经元和骨细胞的发育起关键调控作用的细胞因子 本研究探讨了IL-11对免疫应答的核心细胞之———T淋巴细胞功能的调节作用及其机制,我们在国内外首先发现:I IL-11可直接对T淋巴细胞进行调节作用,IL-11可刺激T细胞一定程度的增殖,若将同样剂量的IL-11加Con A一起作用于T细胞,则可明显增强对T细胞的增殖作用,2 IL-11加 Con A联合刺激T细胞,在该培养上清液中,可明显检测到IL-2、IL-3、IL-4、活性,这可能有临床应用的价值;但未测到IFN-γ和淋巴毒素(LT)活性,IL-11单独刺激T细胞,则无以上各种活性,IL-11这种协同诱导T
Interleukin-11 (IL-11) is a cytokine that plays a key regulatory role in immune response, hematopoiesis, acute inflammatory response, and development of adipocytes, neurons and bone cells. This study explored the effects of IL-11 on immune responses Of the core cells --- T lymphocyte function regulation and its mechanism, we first found at home and abroad: I IL-11 can directly regulate T lymphocytes, IL-11 can stimulate a certain degree of T cell proliferation , If the same dose of IL-11 plus Con A together on T cells, can significantly enhance the proliferation of T cells, 2 IL-11 plus Con A combined stimulation of T cells in the culture supernatant, Significantly, IL-2, IL-3 and IL-4 activity were clearly detected, which may have clinical value. However, IFN-γ and lymphotoxin (LT) activity were not detected and IL-11 stimulated T cells alone The above various activities, IL-11 this synergistic induction of T