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为探讨人脑胶质瘤组织中血管内皮细胞生长因子 (VEGF)表达及其与细胞增殖的关系 ,应用链霉菌抗生物素蛋白 -过氧化物酶连接法 (SABC)免疫组织化学技术检测了 6 7例人脑胶质瘤、8例正常脑组织中 VEGF表达及增殖细胞核抗原 (PCNA)标记指数 (PCNA L I)。结果 VEGF在人脑胶质瘤组织中的阳性表达率为 83.6 %,正常脑组织中无表达 (P<0 .0 0 5 ) ;肿瘤组织中 VEGF表达与 PCNA L I呈显著正相关 (P<0 .0 0 5 )。认为胶质瘤细胞能分泌 VEGF,VEGF表达在肿瘤细胞增殖中起重要作用。
To investigate the expression of vascular endothelial growth factor (VEGF) and its relationship with cell proliferation in human glioma tissue, the expression of vascular endothelial growth factor (VEGF) in human glioma tissue was detected by streptavidinperoxidase-linked immunosorbent assay (SABC) 7 cases of human gliomas, 8 cases of normal brain tissue VEGF expression and proliferating cell nuclear antigen (PCNA) labeling index (PCNA LI). Results The positive expression rate of VEGF in human glioma tissue was 83.6%, which was not found in normal brain tissue (P <0.05). There was a significant positive correlation between VEGF expression and PCNA LI (P <0.05) .0 0 5). It is believed that glioma cells can secrete VEGF. VEGF expression plays an important role in tumor cell proliferation.