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目的探讨头部亚低温治疗新生儿缺氧缺血性脑病的临床疗效。方法将2009年11月—2011年11月本院收治的60例中、重度新生儿缺氧缺血性脑病患儿随机分为观察组(n=30例)和对照组(n=30例),两组均采用降颅压、抗惊厥、维持酸碱平衡及营养支持等治疗,观察组在常规治疗的基础上又加用头部亚低温疗法。观察两组患儿抽搐发生率、存活率,比较两组患儿的NBNA评分。结果观察组患儿抽搐发生率低于对照组,存活率高于对照组;两组生后7、14、28 d NBNA评分比较,亚低温组高于对照组,差异有统计学意义(P<0.05)。结论选择性头部亚低温治疗新生儿HIE是有效的,具有近期及远期的神经保护作用。
Objective To investigate the clinical effect of head hypothermia on neonatal hypoxic-ischemic encephalopathy. Methods Sixty children with moderate to severe hypoxic-ischemic encephalopathy admitted to our hospital from November 2009 to November 2011 were randomly divided into observation group (n = 30) and control group (n = 30) , The two groups were used to reduce intracranial pressure, anticonvulsant, maintain acid-base balance and nutritional support and other treatment, the observation group in addition to the conventional treatment plus head hypothermia therapy. The incidence of convulsions and survival rate in both groups were observed, and the NBNA scores were compared between the two groups. Results The incidence of convulsions in the observation group was lower than that of the control group, and the survival rate was higher than that of the control group. The NBNA scores of the two groups at 7, 14 and 28 days after birth were significantly higher in the mild hypothermia group than in the control group (P < 0.05). Conclusion Selective head mild hypothermia in the treatment of neonatal HIE is effective, with short-term and long-term neuroprotective effect.