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目的探讨高危型人乳头瘤病毒对于宫颈病变患者的影响及临床意义。方法抽取本院2010年3月至2012年3月收治的宫颈癌患者46例及宫颈病变患者32例共同设为研究组。另选取同期收治的患有不同程度宫颈炎患者65例作为对照组。对两组患者均进行了高危型人乳头瘤病毒DNA检测,针对其两组患者病毒感染情况、不同病理宫颈癌病毒感染情况以及不同宫颈病变病毒感染情况进行了分析研究。结果研究组人乳头瘤病毒阳性65例(83.3%),对照组16例(24.6%),差异有统计学意义(P<0.05)。结论高危型人乳头瘤病毒感染是患者宫颈病变的重要因素,也是其引发宫颈癌的重要前提条件。故对此病毒进行定量检测能够对宫颈病变起到有效预测作用,控制此病毒的感染对于预防及治疗宫颈癌具有重要的临床意义。
Objective To investigate the effect of high risk human papillomavirus (HPV) on patients with cervical lesions and its clinical significance. Methods 46 patients with cervical cancer and 32 patients with cervical lesions admitted to our hospital from March 2010 to March 2012 were selected as the research group. Another selection of concurrent treatment of patients with varying degrees of cervicitis in 65 cases as a control group. High-risk human papillomavirus (HPV) DNA was detected in both groups. According to the virus infection status of the two groups, the infection of different pathological cervical cancer virus and the infection of different cervical lesions were analyzed. Results In the study group, 65 cases (83.3%) were positive for HPV and 16 cases (24.6%) in the control group, the difference was statistically significant (P <0.05). Conclusion High-risk human papillomavirus infection is an important factor in patients with cervical lesions, but also an important prerequisite for cervical cancer. Therefore, the quantitative detection of this virus can play an effective role in predicting cervical lesions. Controlling the virus infection has important clinical significance for the prevention and treatment of cervical cancer.