碘葡酰胺(Metrizamide)作为水溶性造影剂应用于临床,有溶解度高,从脑脊液中清除迅速;对脊髓及神经根显影清楚以及几乎无毒等优点.应用碘葡酰胺后,发生急性脑膜炎特别罕见.作者报告一例碘葡酰胺腰脊髓造影后发生急性化学性脑膜炎,其临床表现及脑脊液检查酷似急性细菌性脑膜炎. Metrizamide, as a water-soluble contrast agent, is clinically useful with high solubility, rapid clearance from cerebrospinal fluid, clear imaging of the spinal cord and nerve root, and is almost nontoxic. Acute meningitis occurs particularly after iodoglycamide administration Rare. The authors report a case of acute chemical meningitis following iodoglu-amide lumbar myelography. Its clinical manifestations and cerebrospinal fluid tests resemble acute bacterial meningitis.