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目的探讨 FAIR 作为一种不用对比剂的非侵入性成像方法在肺实质 MRI 灌注成像中的应用价值。方法对20名健康志愿者,用 SSFSE-FAIR 序列进行2个冠状面的扫描(降主动脉中央、肺门层面)。计算不同层面双肺的相对灌注值(rPBF)及其比值(rPBF_R/rPBF_L,R/L)。结果 (1)同层面双肺 rPBF:降主动脉中央层面,左、右肺灌注差异无统计学意义(P>0.05,右侧 rPBF 87±24,左侧 rPBF 87±27);肺门层面,双肺灌注有明显差异(P<0.05,右侧 rPBF 41±15,左侧 rPBF 74±25)。(2)同侧肺组织不同层面 rPBF:双肺 rPBF 在2个不同层面间差异均有统计学意义(均 P<0.05);降主动脉中央层面的 rPBF 均高于肺门层面的 rPBF。结论 FAIR 用于肺实质灌注成像是可行的,由于质子饱和效应的因素,在个别层面左、右肺的灌注有差异;且 FAIR 可以较敏感的反应重力所致的肺血流分布的不均匀性。
Objective To investigate the value of FAIR as a contrast-free, noninvasive imaging method in pulmonary parenchymal MRI perfusion imaging. Methods Twenty healthy volunteers were scanned with two coronal planes (descending aorta and hilar level) with SSFSE-FAIR sequence. The relative perfusion (rPBF) and its ratio (rPBF_R / rPBF_L, R / L) in different lungs were calculated. Results (1) The level of rPBF in bilateral lungs at the same level was not significantly different between the left and right lungs at the central level of the descending aorta (P> 0.05, rPBF 87 ± 24 on the right and rPBF 87 ± 27 on the left) There was a significant difference between the two lung perfusion groups (P <0.05, rPBF right 41 ± 15, left rPBF 74 ± 25). (2) rPBF in different layers of ipsilateral lung tissue: There were significant differences in rPBF of lung between two different levels (all P <0.05). The rPBF in central level of descending aorta was higher than rPBF in hilar level. Conclusions FAIR is feasible for pulmonary perfusion imaging. Because of proton saturation, there are differences in perfusion of left and right lungs at individual levels. FAIR can reflect the non-uniform distribution of pulmonary blood flow more sensitively .