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目的:评价准分子激光原位角膜磨镶术(LASIK)联合遮盖疗法治疗青少年屈光参差性弱视的疗效,并将其与传统光学矫正联合遮盖疗法的疗效进行比较。方法:回顾性病例对照研究,屈光参差性弱视患者19例,年龄10～17岁。A组包括患屈光参差性弱视的青少年10例,光学矫正联合遮盖疗法后,他们的视力不能改善。这些患者后接受LASIK联合遮盖疗法。B组包括年龄相匹配的屈光参差性弱视患者9例作为对照,他们适应光学矫正联合遮盖疗法。分析A组的术后视力,并与B组进行比较。结果:A组,术前平均球性屈光不正度数为-8.9±5.2D,术后为-1.9±2.0D;术前平均最佳矫正视力为0.25±0.18,治疗后提高至0.50±0.26。B组,治疗前平均最佳矫正视力为0.27±0.18,治疗后提高至0.50±0.28。两组治疗后最佳矫正视力相比较,无统计学差异。结论:对于经过传统的光学矫正联合遮盖疗法而不能提高视力的青少年屈光参差性弱视患者,LASIK为他们提供了一个可行的治疗方法,其治疗效果与传统疗法相当。
OBJECTIVE: To evaluate the efficacy of laser in situ keratomileusis (LASIK) combined with masking in the treatment of adolescent anisometropic amblyopia, and to compare its efficacy with conventional ophthalmic correction and masking therapies. Methods: A retrospective case-control study, 19 patients with anisometropic amblyopia, aged 10 to 17 years. Group A included 10 patients with anisometropic amblyopia, and their visual acuity was not improved after optical correction plus masking. These patients underwent LASIK combined with masking therapies. B group, including age-matched patients with anisometropic amblyopia in 9 cases as a control, they adapt to optical correction and masking therapy. A group of postoperative visual acuity, and compared with the B group. Results: In group A, the average preoperative average spherical refractive error was -8.9 ± 5.2D and postoperative was -1.9 ± 2.0D. The average best corrected visual acuity was 0.25 ± 0.18 before surgery and increased to 0.50 ± 0.26 after treatment. In group B, the average best corrected visual acuity was 0.27 ± 0.18 before treatment and 0.50 ± 0.28 after treatment. There was no significant difference between the two groups in the best corrected visual acuity after treatment. CONCLUSIONS: LASIK provides a viable treatment for adolescents with anisometropic amblyopia who can not improve their visual acuity after conventional ophthalmic correction and ophthalmic masking, and their treatment is comparable to traditional therapies.