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[目的]研究基质金属蛋白酶-9(matrix metalloproteinase 9,MMP-9)在肺癌患者侵袭和转移中的意义。[方法]收集肺癌患者血清70例,健康体检者血清60例,通过酶联免疫吸附法(ELISA)检测血清样本中MMP-9的表达水平。[结果]MMP-9在肺癌患者血清中的含量明显高于健康人群;且有淋巴结转移组血清MMP-9水平显著性高于无淋巴结转移组;在不同病理类型肺癌组间MMP-9水平差异无统计学意义。[结论]MMP-9可以作为临床判断肺癌侵袭和转移的生物学指标。
[Objective] To investigate the significance of matrix metalloproteinase 9 (MMP-9) in the invasion and metastasis of lung cancer patients. [Methods] Seventy patients with lung cancer and 60 healthy volunteers were enrolled in this study. Serum MMP-9 levels were detected by enzyme-linked immunosorbent assay (ELISA). [Results] The serum levels of MMP-9 in patients with lung cancer were significantly higher than those in healthy people. The levels of serum MMP-9 in patients with lymph node metastasis were significantly higher than those without lymph node metastasis. The differences in MMP-9 levels among different pathological types of lung cancer No statistical significance. [Conclusion] MMP-9 can be used as a biological index for clinical diagnosis of lung cancer invasion and metastasis.