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目的:总结国内外对前哨淋巴结在结直肠癌领域的研究现状。方法:应用PubMed及CNKI期刊全文数据库检索系统,以“前哨淋巴结、结肠癌和直肠癌”等为关键词,检索1977-01-2009-06的相关文献,共检索到英文文献156条,中文文献62条。纳入标准:1)前哨淋巴结的起源及特点;2)前哨淋巴结微转移的研究;3)前哨淋巴结活检技术的应用研究;4)前哨淋巴结在结直肠癌领域的应用发展。根据纳入标准,纳入分析28篇文献。结果:前哨淋巴结状态可以比较准确地预测结直肠癌区域淋巴结的转移情况,对前哨淋巴结行集中分析有助于发现传统组织病理学检查遗漏的微转移灶及异常淋巴引流途径,从而使部分患者肿瘤分期上调。结论:结直肠癌前哨淋巴结活检是一种切实可行的技术,有望为临床判断区域淋巴结群受累状况提供一种新的手段,从而有助于更准确的肿瘤分期。但仍需进一步大样本前瞻性的研究。
Objective: To summarize the research status of sentinel lymph node in the field of colorectal cancer at home and abroad. Methods: Using PubMed and CNKI full-text database retrieval system, and searching for the literature of “Sentinel lymph node, colon cancer and rectal cancer” from 1977 to 2009, a total of 156 English articles were retrieved, Chinese literature 62. Inclusion criteria: 1) the origin and characteristics of sentinel lymph nodes; 2) the study of sentinel lymph node micrometastases; 3) the application of sentinel lymph node biopsy technology; 4) the application of sentinel lymph node in the field of colorectal cancer. According to the inclusion criteria, 28 articles were included in the analysis. Results: The sentinel lymph node status can predict the metastasis of lymph nodes in colorectal cancer more accurately. The centralized analysis of sentinel lymph nodes can help to find out the micrometastases and abnormal lymphatic drainage missed by traditional histopathological examination, so that some patients with tumors Increase in installments. CONCLUSIONS: Sentinel lymph node biopsy of colorectal cancer is a feasible technique that is expected to provide a new method for judging the status of regional lymph node involvement in clinical practice and thus contribute to more accurate tumor staging. However, further large-scale forward-looking research is still needed.