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目的观察奥扎格雷纳注射液治疗急性脑梗死临床疗效。方法选择急性脑梗死(ACI)住院患者98例,随机分成治疗组(50例)和对照组(48例)。治疗组给予奥扎格雷纳注射液80mg+0.9%氯化钠注射液250mL静脉滴注,1次/d,对照组给予香丹注射液20mL+5%葡萄糖注射液250mL静脉滴注,1次/d。观察2组患者临床疗效及神经功能缺损改善情况,并比较血液流变学指标变化。观察记录不良反应。结果治疗组总有效率优于对照组(分别为94%和72.9%,P<0.05)。神经功能缺损评分及血液流变学指标改善情况亦优于对照组(P<0.05)。2组不良反应差异无统计学意义(P>0.05)。结论奥扎格雷纳注射液治疗急性脑梗死有显著疗效。
Objective To observe the clinical efficacy of Ozagrenal injection in the treatment of acute cerebral infarction. Methods A total of 98 hospitalized patients with acute cerebral infarction (ACI) were randomly divided into treatment group (50 cases) and control group (48 cases). The treatment group was given Ozagrenault injection 80mg + 0.9% sodium chloride injection 250mL intravenous infusion, 1 / d, the control group was given Xiangdan injection 20mL + 5% glucose injection 250mL intravenous infusion, 1 / d. The clinical efficacy and neurological deficits in two groups were observed, and the changes of hemorheology indexes were compared. Observation and record adverse reactions. Results The total effective rate of the treatment group was better than that of the control group (94% and 72.9%, respectively, P <0.05). Neurological deficit scores and improvement of hemorrheological parameters were also better than those of the control group (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Ozagrenal injection has a significant effect in the treatment of acute cerebral infarction.