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至今,一些锕系和镧系放射性核素促排的首选治疗方法仍然是DTPA的静脉内给药法。但是,近来,在应用气溶胶化的DTPA吸入作为交替和可能更有效的一种治疗方式方面,增加了人们的兴趣。这种兴趣是根据以下几方面的考虑:(1)吸入是放射性物质进入人体最可能的途径,而且以吸入DTPA来治疗可能会增加药物-金属互相作用的潜力,从而导致更大的促排效力。(2)病人舒适,DTPA用吸入的重复给药
To date, some of the preferred treatments for promoting actinide and lanthanide radionuclides remain the intravenous route of DTPA. Recently, however, there has been increased interest in the use of aerosolized DTPA inhalation as an alternative and potentially more effective treatment. This interest is based on the following considerations: (1) Inhalation is the most likely way radioactive substances enter the body, and inhalation of DTPA to treat potential increases in drug-metal interactions, leading to greater efficiency . (2) patient comfort, DTPA repeated inhalation