论文部分内容阅读
目的：探讨自由基对胆色素结石形成的影响。方法：用电子顺磁共振谱（ＥＰＲ）分析胆石，用ＦＴ－ＩＲ测定胆红素钙含量。结果：胆固醇结石的ＥＰＲ信号很弱或检测不出。胆色素结石则可同时具有自由基和过渡金属离子的ＥＰＲ特征，其中心谱线（ｇ＝２．００４０，线宽＝９．５Ｇ）由自由基引起，且强度与胆石中胆红素钙的含量正相关（ｒ＝＋０．９９５，Ｐ＜０．００１），结论：胆色素结石中存在源于胆红素类化合物的自由基。自由基对胆色素结五中胆红素聚合物的形成可能有重要影响。
Objective: To explore the impact of free radicals on the formation of bile pigment stones. Methods: The gallstone was analyzed by electron paramagnetic resonance spectroscopy (EPR) and the calcium content of bilirubin was measured by FT-IR. Results: The EPR signal of cholesterol stones is weak or undetectable. Pigmented stone can have both EPR characteristics of free radicals and transition metal ions, the center line (g = 2.0040, line width = 9.5G) caused by free radicals, and the intensity of gallstone bilirubin calcium (R = +0.995, P <0.001). Conclusion: Free radicals derived from bilirubin exist in biliary pigment stones. Free radicals may have a major impact on the formation of bilidin in bili pigmentation.