本文报导了3′,5′—环—磷酸乌苷(cGMP)的二丁酰衍生物(二丁酰 cGMP)对中枢神经系统的药理效应。作者们发现二丁酰 cGMP 直接用于中枢神经系统可对抗伤害性刺激而不引起镇静、呼吸抑制,也不改变对视听刺激的警醒反应或运动活动;并能保护性地对抗高温所致的伤害和死亡。与吗啡不同,二丁酰 cGMP 的镇痛作用不被纳洛酮所阻止或消除。 This article reports on the pharmacological effects of the dibutyryl derivative (dibutyryl cGMP) of 3 ’, 5’-cyclic cGMP on the central nervous system. The authors found that dibutyryl cGMP, used directly in the central nervous system, can counteract nociceptive stimuli without causing sedation, respiratory depression, or alertness or motor activity to audio-visual stimuli; and protects against the effects of high temperatures And death. Unlike morphine, the analgesic effect of dibutyryl cGMP is not blocked or eliminated by naloxone.