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目的:探讨超微粉碎技术在艾叶粉碎中的应用效果及其对艾叶主要成分溶出率的影响。方法:取适量艾叶均分为2份,分别使用普通粉碎机和超微粉碎机进行粉碎获得药粉,经显微镜观察药粉末的形貌,同时采用分光光度法测定主要成分的溶出率。结果:超微粉末的粒度小于普通粉末、总黄酮(主要成分)溶出率显著高于普通粉末,数据对比差异有统计学意义(P<0.05)。结论:在艾叶粉碎时采用超微粉碎技术能够降低粉末的粒度,提升总黄酮的溶出率,值得在药物生产工艺中推广应用。
Objective: To investigate the effect of ultrafine pulverization technology on the mulberry leaves and its influence on the dissolution rate of the main components of the mulberry leaves. Methods: The appropriate amount of leaves were divided into two parts, respectively, using ordinary pulverizer and pulverizer pulverized powder obtained by microscopic observation powder morphology, while the dissolution rate of the main components were determined by spectrophotometry. Results: The particle size of the ultrafine powder was smaller than that of the ordinary powder, and the dissolution rate of the total flavonoids (main component) was significantly higher than that of the ordinary powder. The difference was statistically significant (P <0.05). Conclusion: The use of ultrafine grinding technology to reduce the particle size of powder and increase the dissolution rate of total flavonoids in the process of mulberry leaf mowing is worth promoting in the pharmaceutical production process.