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本文采用24小时胃内PH监测仪对确诊十二指肠溃疡的病人进行前瞻交叉对照研究,观察胃壁细胞H_2受体拮抗剂泰胃美(Tagamet,Cimetidine)和质子泵抑制剂洛赛克(Losec,Omeprazole)的抑酸效果。结果显示泰胃美1600mg静注抑酸时间为12.2±2.2小时,此期胃内PH为5.6±1.2;而洛赛克40mg分别为13.2±2.6小时和PH5.6±1.4。两药均有明显抑酸作用,使用上述剂量效果无显著性差异(P>0.05)。
In this paper, a 24-hour gastric pH monitor was used to prospectively cross-control the patients diagnosed as duodenal ulcer. The effects of Tagamet (Cimetidine), a H 2 receptor antagonist of gastric parietal cells, and Losec , Omeprazole) acid-suppressing effect. The results showed that the stomach and stomach the United States 1600mg intravenous acid-withdrawal time of 12.2 ± 2.2 hours, this period of gastric PH was 5.6 ± 1.2; and Losec 40mg were 13.2 ± 2.6 hours and PH5.6 ± 1.4. Both drugs have significant inhibitory effect, the use of the above dose effect was no significant difference (P> 0.05).