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糖尿病肾病(diabetic nephropathy DN)是糖尿病最常见的并发症之一,是糖尿病患者主要致死的原因。而尿蛋白及血清肌酐、尿素氮的异常则是糖尿病肾病肾功能损害的主要临床表现。尿蛋白测定是反映肾小球滤过功能的常用指标,肌酐是肌酸的代谢产物,绝大部分由肾小球滤过排除体外。
Diabetic nephropathy (DN) is one of the most common complications of diabetes and is the leading cause of death in diabetic patients. The abnormality of urinary protein and serum creatinine and urea nitrogen is the main clinical manifestation of renal impairment in diabetic nephropathy. Urine protein determination is a commonly used index reflecting glomerular filtration function. Creatinine is a metabolite of creatine, and most of it is excluded from the body by glomerular filtration.