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目的对比研究MCu功能性宫内节育器(intrauterine contraceptive device,IUD)、MCuⅡ IUD与MYCu IUD的临床效果和不良反应。方法于节育门诊选择390例育龄妇女随机分为3组,分别放置MCu IUD、MCuⅡ IUD、MYCu IUD各130例,放置后1、3、6、12月进行随访。结果 MCu IUD、MCuⅡ IUD、MYCu IUD3组累计妊娠率分别为0.77%、0.77%、0%;累计脱落率分别为0.77%、0%、0.77%;因不良反应取出率分别为2.39%、2.36%、1.57%,以上各项比较,差异均无统计学意义(P>0.05)。随访1个月时有主诉(不良反应)分别为20.00%、23.08%、10.00%,其中月经异常分别为18.46%、20.77%、8.46%,MCu IUD组与MCuⅡ IUD组均多于MYCu IUD组,差异有统计学意义(P<0.05)。结论 MCu IUD、MCuⅡ IUD、MYCu IUD均具有避孕效果好,脱落率低的特点,值得推广;MCuⅡIUD、MYCuIUD的铜表面积符合国家标准,取出时比MCuIUD有优势;MYCuIUD放置初期不良反应发生率低于MCu IUD、MCuⅡ IUD,但价格略高,建议推广使用中酌情选择。
Objective To compare the clinical effects and adverse reactions of MCu functional intrauterine contraceptive device (IUD), MCuII IUD and MYCu IUD. Methods Three hundred and ewes of childbearing age were selected in an outpatient setting and were randomly divided into 3 groups. There were 130 MCu IUD, MCuII IUD and MYCu IUD respectively. All patients were followed up 1, 3, 6 and 12 months after placement. Results The cumulative pregnancy rates in MCu IUD, MCuII IUD and MYCu IUD3 groups were 0.77%, 0.77% and 0% respectively. The cumulative rates of exfoliation were 0.77%, 0% and 0.77% respectively. The rates of adverse reactions were 2.39% and 2.36% , 1.57% respectively. There was no significant difference among the above comparisons (P> 0.05). The main complaints (adverse reactions) were 20.00%, 23.08% and 10.00% respectively at 1 month follow-up. Among them, menstrual abnormalities were 18.46%, 20.77% and 8.46% respectively. MCu IUD group and MCuII IUD group were more than MYCu IUD group, The difference was statistically significant (P <0.05). Conclusion MCu IUD, MCuII IUD and MYCu IUD all have the advantages of good contraceptive effect and low exfoliation rate. They are worthy of promotion. The surface area of copper in MCuIIIUD and MYCuIUD conforms to the national standard, and is superior to MCuIUD in removal. The incidence of adverse reactions in early stage of MYCuIUD placement is lower than MCu IUD, MCuII IUD, but the price is slightly higher, it is recommended to promote the use of the appropriate choice.